Promoting peripheral myelin repair
نویسندگان
چکیده
منابع مشابه
Myelin Repair Foundation
The Myelin Repair Foundation is pleased to present this annual review of our progress toward achieving our goal of discovering and validating effective new treatment targets for multiple sclerosis. We were extremely pleased by the rapid progress of the team both in advancing frontiers of translational scientific research and demonstrating the power of the MRF Accelerated Research CollaborationT...
متن کاملMyelin Repair Foundation
• Creating new purification and culture techniques for neural cells, • Making new antibodies to visualize protein distribution or control signaling between cells, • Constructing new interfering RNAs and breeding transgenic animals to control gene expression and protein production • Developing new models to study biological mechanisms and evaluate therapeutic effects in cell culture, animal mode...
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To probe into the functional properties of the major peripheral myelin cell surface glycoprotein P0, its ability to confer adhesion and neurite outgrowth-promoting properties was studied in cell culture. To this aim, P0 was expressed as integral membrane glycoprotein at the surface of CV-1 cells with the help of a recombinant vaccinia virus expression system. Furthermore, the immunoglobulin-lik...
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The formation of oligodendrocytes (oligodendrogenesis) and myelin is regulated by several neurotrophic factors. Strategies to increase the level of these trophic molecules may facilitate repair in demyelinating conditions, such as multiple sclerosis (MS). Because leukocytes are a source of neurotrophic factors, and as glatiramer acetate (GA) generates T helper 2 (Th2) lymphocytes that are not k...
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Galectin-1 (Gal-1) is a member of a highly conserved family of animal lectins which binds to the common disaccharide [Galβ(1-4)-GlcNAc] on both Nand O-glycans decorating cell surface glycoconjugates. Current evidence supports a role for Gal-1 in the pathophysiology of multiple sclerosis (MS), one of the most prevalent chronic inflammatory diseases, as approximately one third of MS patients gene...
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ژورنال
عنوان ژورنال: Experimental Neurology
سال: 2016
ISSN: 0014-4886
DOI: 10.1016/j.expneurol.2016.04.007